2026

Murrin, S.,* Woodworth, K.*, Wheeler, B.*, Froom, Z.*, Scott, A., Davenport Huyer, L. Systematic development of degradable polyester biomaterials via ring-opening copolymerization of succinic anhydride and epoxides. Biomacromolecules. In Press.

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2025

Callaghan, N.I.*, Davenport Huyer, L.* Altered metabolism in idiopathic pulmonary fibrosis: advancements in disease modeling, target identification, and therapeutic development., Journal of Cellular Physiology. DOI: 10.1002/jcp.70112

 

Rempe, C.*, Callaghan, N.I.*, Fong-Hollohan, L.*, Nersesian, S., Froom, Z.*, Medd, K.*, Ahmed, I., Karakach, T., Bezuhly, M., Boudreau, J., Davenport Huyer, L. Persistent glycolysis defines the foreign body response to polymeric implants. Science Advances. 2025, 11, 51, eadx63684 DOI: 10.1126/sciadv.adx6368
Highlighted by a research focus article: 10.1126/sciadv.aed8370

 

Wheeler, B.*, Woodworth, K.E.*, Davenport Huyer, L. Development of a multiplexed synthesis platform for controlled polymer polycondensation. Under Review. Preprint Available:10.26434/chemrxiv-2025-jg6fl

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Woodworth, K.E.*, Callaghan, N.I.*, Davenport Huyer, L. Biomaterial strategies for targeted intracellular delivery to phagocytes. Advanced Functional Materials. 2025, e08761. DOI: 10.1002/adfm.202508761

 

Wheeler, B.*, Medd, K.*, Woodworth, K.E.*, Davenport Huyer, L. Molecular and Macroscopic Considerations for Degradable Aliphatic Polyester Biomaterial Design. Biomacromolecules. 2025, 26, 8, 4784–811 DOI: 10.1021/acs.biomac.5c00765

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Froom, Z.S.C.S*., Callaghan, N.I.*, Davenport Huyer, L. Cellular crosstalk in fibrosis: insights into macrophage and fibroblast dynamics. Journal of Biological Chemistry. 2025, 301 (6) 110203. DOI: 10.1016/j.jbc.2025.110203

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Froom, Z.S.C.S.*, Medd, K.*, Wheeler, B.P.*, Osborne, N. D.*, Rempe, C. N.*, Woodworth, K. E.*, Charron, C., Davenport Huyer, L. Antifibrotic Function of Itaconate-Based Degradable Polyester Materials. ACS Biomaterials Science & Engineering 2025 11 (3), 1549-1561. DOI: 10.1021/acsbiomaterials.4c02444

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Woodworth, K. E.*, Froom, Z. S. C. S.*, Osborne, N. D.*, Rempe, C. N.*, Wheeler, B.*, Medd, K.*, Callaghan, N. I.*, Qian, H., Acharya, A. P., Charron, C., Davenport Huyer, L. Development of Itaconate Polymers Microparticles for Intracellular Regulation of Pro-Inflammatory Macrophage Activation. Adv. Healthcare Mater. 2025, 2405257. DOI: 10.1002/adhm.202405257

 

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2024

Callaghan, N. I.*, Rempe, C. N.*, Froom, Z. S. C. S.*, Medd, K. T.*, Davenport Huyer, L. Cell dynamics and metabolism of the foreign body response: characterizing host-biomaterial interactions for next-generation medical implant biocompatibility. Mater. Adv., 2024, 5, 6719-6738. DOI: 10.1039/D4MA00333K

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Bannerman, D., Pascual-Gil, S., Campbell, S., Jiang, R., Wu, Q., Okhovatian, S., Wagner, K. T., Montgomery, M., Laflamme, M. A., Davenport Huyer, L., Radisic, M. Itaconate and citrate releasing polymer attenuates foreign body response in biofabricated cardiac patches. Materials Today Bio, 24, 2024, 100917, 2590-0064. DOI: 10.1016/j.mtbio.2023.100917

 

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2023

Okhovatian, S., Shakeri, A., Davenport Huyer, L., Radisic, M. Elastomeric Polyesters in Cardiovascular Tissue Engineering and Organs-on-a-Chip. Biomacromolecules 2023 24 (11), 4511-4531. DOI: 10.1021/acs.biomac.3c00387

 

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2022

Callaghan, N.I.*, Durland, L.J., Ireland, R.G., Santerre, J.P., Simmons, C.A., Davenport Huyer, L. Harnessing conserved signaling and metabolic pathways to enhance the maturation of functional engineered tissues. npj Regen Med 7, 44 (2022). DOI: 10.1038/s41536-022-00246-3

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Cherry, C., Andorko, J. I., Krishnan, K., Mejías, J. C., Nguyen, H. H., Stivers, K. B., Gray-Gaillard, E. F., Ruta, A., Han, J., Hamada, N., Hamada, M., Sturmlechner, I., Trewartha, S., Michel, J. H., Davenport Huyer, L., Wolf, M. T., Tam, A. J., Peña, A. N., Keerthivasan, S., Le Saux, C. J., Fertig, E. J., Baker, D. J., Housseau, F., van Deursen, J. M., Pardoll, D. M., Elisseeff, J. H. Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies. GeroScience 45, 2559–2587 (2023). DOI: 10.1007/s11357-023-00785-7​

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2021

Moore, E., Maestas, D.R., Cherry, C. C., Garcia, J.A., Comeau, H.Y., Davenport Huyer, L, Blosser, R.L., Rosson, G.D., Elisseeff, J.H. Biomaterials direct functional B cell response in a material specific manner. Science Advances, 7(49), eabj5830. DOI: 10.1126/sciadv.abj5830 

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Shou, Y., Campbell, S., Radisic, M., Davenport Huyer, L. Towards renewable and functional biomedical polymers with tunable degradation rates based on itaconic acid and 1,8-octanediol. ACS Applied Polymer Materials (Cover article). 2021, 3 (4): 1943-55. Link to paper 

Lai, B.F., Lu, R.X., Davenport Huyer, L., Kakinoki, S., Yazbeck, J., Wang, E.Y., Wu, Q., Zhang, B., Radisic, M. A well-plate based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature. Nature Protocols. 2021, 16: 2158-89. DOI: 10.1038/s41596-020-00490-1

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Lu, R.X, Lai, B.F., Benge, T., Wang, E.Y., Davenport Huyer, L., Rafatian,N., Radisic, M. Heart-on-a-chip platform for assessing toxicity of air pollution related nanoparticles. Advanced Material Technologies. 2021, 6 (2): 2000726. DOI: 10.1002/admt.202000726

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Davenport Huyer, L , Mandla, S., Wang, Y., Yee, B., Euler, C., Lai, B.F., Bannerman, D., Lin, Y., Montgomery, M., Nemr, K., Mahadevan, R., Bender, T., Epelman, S., Radisic, M. Macrophage immunomodulation through new polymers that recapitulate functional effects of itaconate as a power house of innate immunity. Advanced Functional Materials. 2021, 31 (6): 2003341. DOI: 10.1002/adfm.202003341

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Davenport Huyer, L., Radisic, M. An organ-on-a-chip system to study anaerobic bacteria in intestinal health and disease. Med. 2021, 2 (1): 16-18. DOI: 10.1016/j.medj.2020.12.016

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2020

Callaghan, N.I.*, Khaira, S., Ouyang, A., Cadavid, J.L. Chang, H., Co, I.L., Diep, P., Ivanov, N., Li, G., Li, N.T., Tran-Nguyen, N. Smith, C., Davenport Huyer, L., Kilkenny, D.M. (co-corresponding author). Discovery: Virtual implementation of inquiry-based remote learning for secondary STEM students during the COVID-19 pandemic. Biomedical Engineering Education. 2020, 1 (1): 87-94. DOI: 10.1007/s43683-020-00014-z

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Davenport Huyer, L., Callaghan, N. I, Dicks, S., Scherer, E., Shukalyuk, A. I., Jou, M., Kilkenny, D. M. A scalable inquiry-based curriculum enhances differential engagement and academic performance for senior high school STEM students. npj Science of Learning. 2020, 5 (1): 1-12. DOI: 10.1038/s41539-020-00076-2. Summary blog post available: https://go.nature.com/3oDKolE

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Lai, B.F., Lu, R. X., Hu, Y., Davenport Huyer, L., Dou, W., Radulovich, N, Tsao, M. S., Sun, Y., Radisic, M. Recapitulating pancreatic tumor microenvironment through synergistic use of patient organoids and organ-on-a-chip vasculature. Advanced Functional Materials. 2020, 30 (48): 2000545. DOI: 10.1002/adfm.202000545

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Bannerman, A. D., Davenport Huyer, L., Montgomery, M., Zhao, N., Velkonja, C., Radisic, M., Elastic biomaterial scaffold with spatially varying adhesive design. Advanced Biosystems. 2020,4 (8), 20000046. DOI: 10.1002/adbi.202000046

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Davenport Huyer, L., Pascual-Gil, S., Wang, Y., Mandla, S., Yee, B., Radisic, M. Advanced strategies for modulation of the material-macrophage interface. Advanced Functional Materials. 2020, 30 (44), 1909331. DOI: 10.1002/adfm.201909331

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Savoji, H., Davenport Huyer, L., Mohammadi, M.H., Lai, B.F.L, Bannerman, D., Shoaib, M., Bobicki, E., Radisic, M. 3D printing of microvasculature using bioelastomer prepolymers by freeform reversible embedding. ACS Biomaterials Science & Engineering (Cover Article). 2020. 6 (3): 1333-1343. DOI: 10.1021/acsbiomaterials.9b00676

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2019

Mandla, S., Davenport Huyer, L., Wang, Y., Radisic M. Macrophage polarization with angiopoietin-1 peptide QHREDGS. ACS Biomaterial Science & Engineering. 2019. 5 (9): 4542–4550; DOI: 10.1021/acsbiomaterials.9b00483

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Davenport Huyer, L., Bannerman D., Wang, Y., Savoji, H., Knee-Walden, E.J., Brissenden, A., Yee, B., Shoaib, M., Bobicki, E., Amsden, B.G., Radisic, M. One-pot synthesis of unsaturated polyester bio-elastomer with controllable material curing for microscale designs. Advanced Healthcare Materials (Cover Article). 2019. 8 (16): 1900245; DOI: 10.1002/adhm.201900245

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Wang, E.Y., Rafatian, N., Zhao, Y., Lee, A., Lai, B.F., Lu, R.X., Jekic, D., Davenport Huyer, L., Knee-Walden, E.J., Bhattacharya, S., Backx, P.H., Radisic, M. Biowire model of interstitial and focal cardiac fibrosis. ACS Central Science (Cover Article). 2019. 5 (7): 1146-1158; DOI: 10.1021/acscentsci.9b00052

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Zhao, Y., Wang, E.Y, Davenport Huyer, L., Liao, Y., Yeager, K., Vunjek-Novakovic, G., Radisic, M., Zhang, B. A multimaterial microphysiological platform enabled by rapid casting of elastic micro-wires. Advanced Healthcare Materials (Cover Article). 2019. 8 (5):  ; DOI: 10.1002/adhm.201801187

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Zhao, Y., Rafatian, N., Feric, N., Cox, B., Aschar-Sobbu, R., Wang, E.Y., Aggarwal, P., Zhang, B., Conant, G., Ronaldson-Bouchard, K., Pahnke, A., Protze, S., Lee, J. H., Davenport Huyer, L., Jekic, D., Wickeler, A., Naguib, H., Keller, G., Vunjak-Novakovic, G., Broeckel, U., Backx, P. H., Radisic, M. A platform for generation of chamber-apecific cardiac tissues and disease modeling. Cell. 2019. 176 (4): 913-927; DOI: 10.1016/j.cell.2018.11.042

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2018

Chen, F., Qi, R., Davenport Huyer, L., Amsden, B. Degradation of poly(5-hydroxy-trimethylene carbonate) in aqueous environments. 2018. Polymer Degradation and Stability .158: 83-91; DOI: 10.1016/j.polymdegradstab.2018.10.022

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Zhang, B., Lai, B.F.L, Xie, R., Davenport Huyer, L., Montgomery, M., Radisic, M. Microfabrication of AngioChip, a biodegradable polymer scaffold with microfluidic vasculature. Nature Protocols (Cover Article). 2018. 13 (8): 1793-1813; DOI: 10.1038/s41596-018-0015-8

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Mandla, S., Davenport Huyer, L. (co-first author),  Radisic, M. Multimodal bioactive material approaches for wound healing. APL Bioengineering. 2018. 2 (2): 021503; DOI: 10.1063/1.5026773

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Montgomery, M., Davenport Huyer, L., Bannerman, D., Radisic, M. Method for the fabrication of elastomeric polyester scaffolds for tissue Engineering and minimally invasive delivery. ACS Biomaterials Science & Engineering. 2018. 4 (11): 3691-3703; DOI: 10.1021/acsbiomaterials.7b01017

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2017

Montgomery, M. , Ahadian S. , Davenport Huyer, L., Rito, M. L., Civitarese, R. A., Vanderlaan, R. D., Wu, J., Reis, L., Momen, A., Akbari, S., Pahnke, A., Li, R. K., Caldarone, C., Radisic, M. Flexible shape-memory scaffold for minimally invasive delivery of functional tissues. Nature Materials (Cover Article). 2017. 16: 1038–1046; DOI: 10.1038/nmat4956

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Lai, B.F.L, Davenport Huyer, L., Lu, R.X.Z, Drecun, S., Radisic, M.‡, Zhang, B.‡ InVADE: Integrated vasculature for assessing dynamic events. Advanced Functional Materials (Cover Article). 2017. 27 (46): 1703524; DOI: 10.1002/adfm.201703524

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Ahadian, S., Civitarese, R. Bannerman, D. Mohammadi, M.H. Lu, R., Wang, E.Y., Davenport Huyer, L., Lai, F., Zhang, B., Zhao, Y., Mandla, S., Korolj, A., Radisic, M. Organ-on-a-chip platforms: A convergence of advanced materials, cells, and microscale technologies. Advanced Healthcare Materials. 2017. 7 (2): 1700506; DOI: 10.1002/adhm.201700506

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Ahadian, S., Davenport Huyer, L. (co-first author), Estill, M., Yee, B., Smith, N., Zhensong, X., Sun, Y., Radisic, M. Moldable elastomeric polyester-carbon nanotube scaffolds for cardiac tissue engineering. Acta Biomaterialia. 2017. 52: 81-91; DOI: 10.1016/j.actbio.2016.12.009

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2016 and earlier

Davenport Huyer, L., Zhang, B., Montgomery, M., Korolj, A., Drecun, S., Conant, G., Zhao, Y., Reis, L., Radisic, M. Highly elastic and moldable polyester biomaterial for tissue engineering applications. ACS Biomaterials Science & Engineering. 2016. 2 (5): 780-788; DOI: 10.1021/acsbiomaterials.5b00525

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Davenport Huyer, L., Montgomery, M., Zhao, Y., Xiao, Y., Conant, G., Korolj, A., & Radisic, M. Biomaterial based cardiac tissue engineering and its applications. Biomedical Materials. 2015. 10 (3): 034004; DOI: 10.1088/1748-6041/10/3/034004

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Zhang, B., Montgomery, M., Davenport Huyer, L., Korolj, A., Radisic, M. Platform technology for scalable assembly of instantaneously functional mosaic tissues. Science Advances. 2015. 1 (7): e1500423; DOI: 10.1126/sciadv.1500423

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Pahnke, A., Conant, G., Davenport Huyer, L., Zhao, Y., Radisic M. The role of Wnt regulation in heart development, cardiac repairand disease: a tissue engineering perspective. Biochemical and Biophysical Research Communications. 2015. 473 (3): 698-703; DOI: 10.1016/j.bbrc.2015.11.060