OUR RESEARCH FOCUS
By coupling immunophenotyping with biomaterial innovation, we decode immune-material interactions to guide the development of targeted therapies for chronic inflammation and fibrosis.
Elucidating biomaterial associated inflammation & fibrosis
The immune cell environment at the host-material interface is complex, involving a number of cell types, signalling pathways, and cell behaviour. Using animal models, patient samples, and in vitro cell culture, we are actively working to better understand this cell behaviour with transcriptomics, metabolomics, and multi-parameter flow cytometry.
Objective-oriented polyester material design
Polyester materials have broad reaching clinical opportunity to support short-term efficacy and subsequent resorption in situ, but are limited by well-described formulations. Through data-driven synthesis approaches focused on throughput and reproducibility, we are developing novel co-polymer formulations to expand the opportunity in polyester device development
Immunoregulatory drug delivery technologies
Degradable materials form the basis to many implantable medical devices, including sutures, support meshes, and coatings. We are interested in precision tunability through material design, balanced with immune-regulatory functionality that incorporates small molecule regulatory metabolites as structural building blocks in polyester backbones.
