Our Research Focus
By coupling immunophenotyping with biomaterial innovation, we decode immune-material interactions to guide the development of targeted therapies for chronic inflammation and fibrosis.
Elucidating biomaterial associated inflammation & fibrosis
The immune cell environment at the host-material interface is complex, involving a number of cell types, signalling pathways, and cell behaviour. Using animal models, patient samples, and in vitro cell culture, we are actively working to better understand this cell behaviour with gene expression, metabolomics, and multi-parameter flow cytometry.
Objective-oriented polyester material design
Metabolism is an exciting therapeutic avenue in immunoregulation, where therapeutic molecules are potential building blocks to diverse polymer strategies. We are currently focused on generating a library of materials to combat the host response across multiple immune cell types.
Immunoregulatory drug delivery technologies
Degradable materials form the basis to many implantable medical devices, including sutures, support meshes, and coatings. We are interested in precision tunability through material design, balanced with immune-regulatory functionality.
